In Star Trek, a radiogenic particle is a type of radioactive particle, found in low concentrations in space and in higher concentrations associated with various natural or artificial phenomena. Radiogenic particles in sufficient quantities can serve as an alternate power source for starships, though this is only safe with a properly modified conversion matrix. (VOY: "Dragon's Teeth")

Class T clusters, such as the one explored by the Delta Flyer in 2376, contain radiogenic sources. After the Flyer was damaged by an encounter with a dark matter lifeform, Captain Kathryn Janeway took the Flyer into a radiogenic ring around a class T planet, hoping to reinitialize the warp reaction by beaming particles directly into the reaction chamber. However, the approach of more dark matter lifeforms forced her to ignite a chain reaction in the rings instead, using the Flyer's phasers. (VOY: "Good Shepherd"). In 2377, Lieutenant Reginald Barclay speculated that a radiogenic field might be preventing his datastream from reaching Voyager. (VOY: "Inside Man").

In real science, the term radiogenic refers to any substance that is produced by a process of radioactive decay. Lead is perhaps the best example of a radiogenic substance, as it is produced from the radioactive decay of uranium and thorium. Specifically, Pb-206 is formed from U-238, Pb-207 from U-235, and Pb-208 from Th-232. Other substances considered radiogenic are argon-40, formed from radioactive potassium, and nitrogen-14, which is formed by the decay of carbon-14. U-238, U-235, and Th-232 themselves are likely to be radiogenic as well, being formed from the decay of those nuclei of the elements heavier than uranium which do not undergo spontaneous fission, just after they were formed in stellar supernovae. Other important examples of radiogenic elements are radon and helium, both of which form during the decay of heavier elements in bedrock. The global supply of helium is radiogenic.

Radiogenic isotopes form some of the most important scientific tools used today in radiometric dating or as an isotopic tracer in isotope geochemistry.