In 2375, Odo and the sixth clone of Weyoun attempted to evade pursuing Jem'Hadar attack ships by hiding in a Kuiper belt, taking their runabout into the interior of a large chunk of ice and powering down. The Jem'Hadar forced them out of hiding by destroying every large ice chunk in range. (DS9: "Treachery, Faith and the Great River").

In actual fact, the Kuiper belt is a region of our outer solar system that is populated by an estimated ten billion to one trillion rock-ice bodies known as Kuiper Belt objects (KBOs). It stretches from about 30 AU from the Sun (Neptune's distance) to at least 150 AU and forms an inner, flattened extension of the Oort cloud.

It is similar to the asteroid belt, although it is far larger -- 20 times as wide and 20–200 times as massive. Like the asteroid belt, it consists mainly of small bodies (remnants from the Solar System's formation). It is home to at least three dwarf planets – Pluto, Haumea and Makemake. But while the asteroid belt is composed primarily of rock and metal, the Kuiper belt objects are composed largely of frozen volatiles (dubbed "ices"), such as methane, ammonia and water.

The Kuiper Belt is thought to be the source of short-period comets and of centaurs.